Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Shimizu Shino 滋賀医科大学, 医学部, 医員 (50505592)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Takeshi 滋賀医科大学, 医学部, 教授 (00206202) ; TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アルツハイマー病 / 早期診断 / ヒト鼻腔 / アミロイドβ / タウ蛋白 / 嗅粘膜

Outline of Final Research Achievements

We have shown that we can detect significant concentration of amyloid-beta or Tau protein in human nasal cavity samples. We have reported the method to measure amyloid-beta in nasal cavity samples. Moreover, we had a clinical study for diagnosis of Alzheimer's Disease using nasal cavity samples. The data of the clinical study are under analysis.

Free Research Field

耳鼻咽喉科学