Olfactory training in daily diet and imaging analysis for the olfactory nerve regeneration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462670
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa Medical University
• Principal Investigator: SHIGA Hideaki 金沢医科大学, 医学部, 准教授 (80436823)
• Co-Investigator(Renkei-kenkyūsha): TAKI Junichi 金沢大学, 附属病院, 講師 (10251927) ; KINUYA Seigo 金沢大学, 医学系, 教授 (20281024) ; WASHIYAMA Kohshin 金沢大学, 保健学系, 助教 (80313675) ; AMANO Ryohei 金沢大学, 保健学系, 教授 (30111769) ; YAMAMOTO Junpei 金沢医科大学, 医学部, 助教 (20460371)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 嗅覚 / リハビリテーション / 再生医学

Outline of Final Research Achievements

The subjects with olfactory disorders were randomly selected from among patients who received follow-up visits at the smell clinic at the Kanazawa Medical University Hospital and who gave written informed consent. The subjects were randomized to the nasal stimulation group or the oral stimulation group in the clinical trials with three months olfactory rehabilitation. The achievement ratio of self-training was not significantly different between the two groups. Olfactory thresholds were not improved after three months olfactory rehabilitation in both groups. The olfactory transport of nasally administered thallium-201 was reduced in the patients with olfactory disorders in clinical trials with olfacto-scintigraphy. Furthermore, the nasal transport of insulin-like growth factor-1 to the brain was inhibited in mice with the resected olfactory bulbs.

Free Research Field

嗅覚障害