Analysis of abnormal micro RNA expression associated with HPV-related head and neck carcinogenesis and prognosis using microarray.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: Ishida Eiichi 東北大学, 医学(系)研究科(研究院), 非常勤講師 (50644811)
• Co-Investigator(Kenkyū-buntansha): Ogawa TAKENORI 東北大学, 大学病院, 講師 (50375060) ; HORII Akira 東北大学, 医学(系)研究科(研究院), 教授 (40249983) ; SAIKI Yuriko 東北大学, 医学(系)研究科(研究院), 助教 (80311223)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: HPV / ヒトパピローマウイルス / 鼻副鼻腔内反性乳頭腫 / 鼻副鼻腔癌 / 原発不明頭頸部癌 / 中咽頭癌 / マイクロＲＮＡ

Outline of Final Research Achievements

In recent years, the prevalence of human papilloma virus (HPV)-related oropharyngeal cancer is increasing in European countries and the United States, and it is also becoming increasingly relevant in clinical practice in Japan. In response to this, we widely elucidated the association of HPV in Japanease head and neck cancer cases, such as oropharyngeal cancer and sinonasal cancer coexistent with inverted papilloma. In addition, as a result of the micro RNA microarray using extracted RNA from formalin-fixed paraffin-embedded oropharyngeal cancer specimens, we revealed micro-RNAs showing specific changes in expression in Japanese HPV-related oropharyngeal cancer cases. These could be implemented as a new prognostic or carcinogenic biomarker of HPV-related oropharyngeal cancer in the future.

Free Research Field

耳鼻咽喉科学、頭頸部外科学