New treatment for IgG4-related disease as new molecules

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Yamagata University
• Principal Investigator: Ohta Nobuo 山形大学, 医学部, 非常勤講師 (20282212)
• Co-Investigator(Kenkyū-buntansha): Ota Yuko 羽陽学園短期大学, 幼児教育科, 准教授 (40442016) ; Ueki Shigeharu 秋田大学, 医学部, 准教授 (60361234) ; Yoshitake hiroshi 順天堂大学, 医学部, 非常勤講師 (00396574) ; Abe Yasuhiro 山形大学, 医学部, 助教 (80420058) ; Takeda Yuji 山形大学, 医学部, 助教 (90302299)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: IgG4関連疾患 / ミクリッツ病 / EBウイルス

Outline of Final Research Achievements

IgG4-related disease is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion with fibrotic or sclerotic changes in affected organs. The copy number of EBV DNA in the affected salivary gland(s) was upregulated in the affected tissues. These results suggest that the copy number of EBV DNA could be useful as a novel biomarker and therapeutic target in IgG4-related disease.

Free Research Field

耳鼻咽喉科学