Regerative medicine for vocal fold scar with cell therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University
• Principal Investigator: Hirano Shigeru 京都大学, 医学(系)研究科(研究院), 准教授 (10303827)
• Co-Investigator(Kenkyū-buntansha): KANEMARU Shin-ichi 田附興風会北野病院, 部長 (00271510) ; NAKAMURA Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908) ; TATEYA Ichiro 京都大学, 大学院医学研究科, 講師 (20526363) ; KITAMURA Morimasa 京都大学, 大学院医学研究科, 助教 (60543262)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 声帯 / 再生医療 / 幹細胞

Outline of Final Research Achievements

This research aims to develop regenerative medicine for the vocal fold with cell transplant. Mesenchymal stem cells derived from the bone marrow or fat improved histological and functional aspects of canine scarred vocal folds. ASC showed higher gene expression of HAS and HGF from vocal fold cells, which appeared beneficial for vocal fold regeneration. Collagen/gelatin scaffold was developed that control-release growth factors. The scaffold proved a good biocompatibility to vocal fold fibroblasts, and indicated regenerative effects on canine vocal fold scar.

Free Research Field

耳鼻咽喉科