2015 Fiscal Year Final Research Report
Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration
| Project/Area Number |
25462694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSUNOKI Takeshi 順天堂大学, 医学部, 教授 (30248025)
IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 扁桃炎 / IL-17 / CD4 / リンパ球 |
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| Outline of Final Research Achievements |
We demonstrated the relevance of IL-17 to chronic tonsillitis, tonsillar hypertrophy, and focus infection. The expression of IL-17 protein was investigated by FACS and Western blotting using tonsillar lymphocytes and peripheral blood lymphocytes. The localization and expression of IL-17 was differed among several disorders. The B cells inside tonsillar tissues stimulated by pokeweed mitogen resulted in a significant contribution to production of IL-17 antibodies.
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| Free Research Field |
耳鼻咽喉科学
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