The study for tissue engineered peripheral nerve regeneration preventing from misdirection

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462698
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: The Tazuke Kofukai
• Principal Investigator: KANEMARU Shinichi 公益財団法人田附興風会, 医学研究所 第5研究部, 研究主幹 (00271510)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 神経再生 / 過誤支配 / 人工神経 / コラーゲン / ゼラチンスポンジ / 単核球

Outline of Final Research Achievements

It is the most important for functional regeneration of the peripheral nerve to prevent from misdirection. The aim of this study was to select the best scaffold enter into the artificial nerve conduit and to elucidate the role of monocyte in the process of nerve regeneration for the purpose of promoting functional regeneration of the peripheral nerve.
This study showed that the gelatin sponge, we expected at first, was not adequate scaffold for regeneration of the peripheral nerve. We focused on Wallerian degeneration in the early process of nerve regeneration and performed the study of implantation of monocyte as the leading factor for it. However, implantation of monocyte did not promote functional regeneration of the peripheral nerve.

Free Research Field

再生医療