The effect of 17beta-estradiol for uveitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nagasaki University
• Principal Investigator: FUJIKAWA Azusa 長崎大学, 病院(医学系), 講師 (60363503)
• Co-Investigator(Kenkyū-buntansha): TSUIKI Eiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493) ; KITAOKA Takashi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235) ; SUZUMA Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: エストロゲン / 網膜色素上皮 / 組織電気抵抗

Outline of Final Research Achievements

We investigated transepithelial resistance (TER) on porcine retinal pigment epithelium (RPE) after various stimulation added. We used Tumor necrosis factor alpha (TNF-α）, 17β-estradiol, vascular endothelial growth factor (VEGF), rebamipide as a stimulation. TER has been reduced to 60% after TNF-α added. But if 17β-estradiol added 2 hour before TNF-α stimulation, the TER was not reduced. We suggest 17β-estradiol prevents TNF-α damage in RPE. TER wasn’t reduced after VEGF added. When rebamipide added 2 hour before TNF-α stimulation, the TER was reduced. We suggest rebamipide doesn’t prevent barrier function of RPE.

Free Research Field

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