2016 Fiscal Year Final Research Report
The inhibition of fibronectin ED-A suppresses the development of proliferative vutreoretinopathy
| Project/Area Number |
25462722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Oita University |
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Principal Investigator |
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| Research Collaborator |
YOKOYAMA Katsuhiko
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 増殖硝子体網膜症 / TGF-β2 / 網膜色素上皮細胞 / 細胞外マトリックス / fibronectin ED-A |
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| Outline of Final Research Achievements |
TGF-β2 induces epithelial mesenchymal transition (EMT) in retinal pigment epithelium (RPE). Therefore, it has been implicated as the key mediator of proliferative vitreoretinopathy. Type I collagen and fibronectin ED-A production were activated by TGF-β2 in RPE. Anti-fibronectin ED-A antibody inhibited TGF-β2-induced type I collagen mRNA expression and type I collagen synthesis. Fibronectin ED-A may be a new therapeutic target for treating proliferative vitreoretinopathy.
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| Free Research Field |
眼科学
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