Analysis of genotypes and clinical features of uveitis caused by herpes viruses

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Takase Hiroshi 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20451940)
• Research Collaborator: KAMOI Koju 東京医科歯科大学, 眼科, 講師 (40451942)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ぶどう膜炎 / 急性網膜壊死 / 虹彩炎 / 水痘帯状疱疹ウイルス

Outline of Final Research Achievements

Varicella-zoster virus (VZV) can cause anterior uveitis or acute retinal necrosis. Although those two disease categories have some common features such as granulomatous uveitis or cause increased intraocular pressure, they are distinctly different diseases because anterior uveitis caused by VZV does not develop acute retinal necrosis, and vice versa. We conducted genotyping analysis by identifying the single nucleotide polymorphism of the open reading frames of VZV from the intraocular fluid of those two different diseases. So far, VZV from the intraocular fluid of both two diseases are classified to be Clade 2. We are continuously analyzing the genotyping of VZV focusing on the gene mutation of glycoprotein E in addition to the open reading frames. Besides the genotyping of VZV, we are developing new comprehensive PCR system to detect VZV and other pathogens simultaneously. We also identified characteristic feature of acute retinal necrosis in fluorescein angiography.

Free Research Field

眼科学