Production of the surgical device for human iPS cell–derived retinal pigment epithelium transplantation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Kiryu Junichi 川崎医科大学, 医学部, 教授 (80281096)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 網膜色素上皮細胞 / iPS細胞

Outline of Final Research Achievements

We successfully conducted transplantation of a hiPSC-RPE cell sheet into a patient with AMD as the first-in-human trial using hiPSCs. AMD lesion, which is 3.0 mm in diameter, requires a 3.0 x 3.0 mm graft, however the surgical device in current use is possible to transplant less than 1.3 x 3.0 mm grafts. Therefore, we produced a surgical device which is possible to transplant a 3.0 x 3.0 mm graft via 1.5 mm scleral wound. The suction port of the device was designed on the lateral side in the insertion direction and the inside of device was processed to be able to store a 3.0 x 3.0 mm grafts. The device is possible to transplant grafts larger than scleral wound.

Free Research Field

眼科分野