2015 Fiscal Year Final Research Report
Effects of ASK1 and Dock family members on the modulation of optic neuritis
| Project/Area Number |
25462766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HARADA Chikako 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (20435720)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 視神経炎 / ASK1 / Dock8 |
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| Outline of Final Research Achievements |
We examined the effects of ASK1, one of the stress response genes, on the severity of optic neuritis in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Clinical signs of EAE were mild in glia-specific ASK1 conditional knockout mice. We also examined the effect of Dock8, an atypical guanine nucleotide exchange factor, on EAE, and found that optic neuritis was mild in Dock8 deficient mice.
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| Free Research Field |
眼科学
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