2016 Fiscal Year Final Research Report
A study of microRNA expression in biliary atresia
| Project/Area Number |
25462768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 胆道閉鎖症 / 予後 / microRNA / 網羅的解析 |
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| Outline of Final Research Achievements |
In this study, we comprehensively analyzed microRNA expression status using liver biopsy in biliary atresia patients. Furthermore, we evaluated a relationship between microRNA expression status and clinical status.
On the basis of comprehensive microRNA expression study, proposed prognostic factors were picked up by gene ontology analysis. The quantitative analysis using real-time PCR were performed in these proposed factors.
In this study, microRNA might play a crucial role in development of biliary atresia. Therefore, biliary atresia patients might be stratified in accordance with microRNA expression status.
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| Free Research Field |
小児外科学
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