Neuroblastoma stage 4S: analysis of multifocal development and spontaneous regression mechanism using iPS cell disease model

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462778
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Fumino Shigehisa 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40405254)
• Co-Investigator(Kenkyū-buntansha): TAJIRI Tatsuro 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 4s神経芽腫 / iPS細胞 / 神経堤幹細胞

Outline of Final Research Achievements

For developing iPS cell disease model of Stage 4s neuroblasoma, we converted normal human fibroblast into IPS cells. Moreover, we tried to differentiate iPS cell to neural crest stem cell, but it failed.
Next, we tried to co-culture hMSC and human neuroblastoma cell line in order to clarify the differentiation of the neurolbastoma cells. Finally, we observed the neurite elongation of neuroblastoma cells.
From this results, we are going to analyze the therapeutic potential of hMSCs as novel diffrentiation therapy of neurolbastoma.

Free Research Field

小児悪性固形腫瘍