2015 Fiscal Year Final Research Report
Basic research on Photodynamic Therapy in pediatric refractory cancer
| Project/Area Number |
25462784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Watanabe Toshihiko 国立研究開発法人国立成育医療研究センター, 外科, 医師 (50306734)
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| Co-Investigator(Renkei-kenkyūsha) |
Okita Hajime 慶應義塾大学, 病理学教室, 准教授 (50317260)
Kuroda Tatsuo 慶應義塾大学, 小児外科学教室, 教授 (60170130)
Rii Kou 国立成育医療研究センター, RI管理室, 室長 (60321890)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 難治性小児固形腫瘍 / 光線力学的治療 |
|---|
| Outline of Final Research Achievements |
5-aminolevurinic acid (5-ALA) induced apoptosis of tumor cells by promoting accumulation of intra-cellular PpIX in time and concentration dependent manner in pediatric neuroblastoma cell line. For future prospect, investigations on the effect of 5-ALA in vivo is needed.
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| Free Research Field |
小児悪性腫瘍
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