Development of artificial nerve made to order combined with stem cells.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462788
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Osaka University
• Principal Investigator: Ko Hosokawa 大阪大学, 医学(系)研究科(研究院), 教授 (20181498)
• Co-Investigator(Kenkyū-buntansha): TOMITA KOICHI 大阪大学, 医学系研究科, 助教 (90423178) ; NISHIBAYASHI AKIMITSU 大阪大学, 医学部付属病院, 医員 (00647133) ; KANAZAWA SHIGEYUKI 大阪大学, 医学系研究科, 招へい教員 (50506243)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 末梢神経 / 脂肪組織由来間葉系幹細胞 / 人工神経

Outline of Final Research Achievements

For the peripheral nerve defects greater than 3cm, transplantation of autologous nerve graft (ANG) is the only therapeutic option. However, ANG has several limitations, such as need for sacrifice of donor nerve and size mismatch between ANG and recipient nerve. The purpose of this study was the development of artificial nerve made-to-order that can be a substitute for ANG. The hybrid artificial nerve was produced by adding Schwann-like cells differentiated from adipose-derived stem cells to the acellular rat peripheral nerves. Although most of the added cells were replaced with the native Schwann cells in the recipient nerve, it accelerated the functional recovery, possibly by producing neurotrophic factors such as brain-derived neurotrophic factor.

Free Research Field

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