Basic studies on the autologous cure by manufacturing plateles

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462800
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Keio University
• Principal Investigator: Yazawa Masaki 慶應義塾大学, 医学部(信濃町), 講師 (60327567)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 再生医学

Outline of Final Research Achievements

Platelets are released from mature megakaryocytes and have an essential role in hemostatic plug formation. Recently, a line of evidence supports the clinical application of platelets to accelerate wound healing. However, it is difficult to use peripheral platelets for wide-range wound. Thus, new strategies for manufacturing megakaryocytes and subsequently platelets are urgently needed. Thus, the use of pre-adipocytes from adipose tissues would be advantageous for establishing a culture system to produce platelets for clinical application. Pre-adipocyte-derived platelets have the ability of activation and contain cytokines in relation to wound healing. We also examined the effect of pre-adipocyte-derived platelets on wound healing of immunodeficient NOG mouse with full-thickness excisional wound. Taken together, manufacturing platelets from pre-adipocytes would be advantageous for wound healing.

Free Research Field

医歯薬学