2015 Fiscal Year Final Research Report
Exploration of mechanisms underlying organ-specific aberrant VEGF signaling in sepsis and development of innovative therapeutic approaches based on microcirculation
| Project/Area Number |
25462812
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 敗血症 / 外科系臨床医学 / 救急医学 / 集中治療学 |
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| Outline of Final Research Achievements |
We found vascular endothelial growth factor (VEGF) is a potential factor for the development of multiple organ dysfunction syndrome (MODS) in sepsis. And VEGF has organ and tissue specific role and function in MODS in sepsis. In the current project, we used various pharmacological interventions for the treatment of MODS from early sepsis, some drugs like endothelin blockade, TNF-alpha blockade, protease activated receptor 2 (PAR2) blockade, VEGF receptor antagonist, ultra-short acting beta blocker as therapeutics for MODS in sepsis.
In this report, we are providing in details how downregulated VEGF in heart tissue in early sepsis can be reversed with the treatment of an ultra-short acting beta blocker, landiolol hydrochloride. Indeed, myocardial dysfunction is a common complication in sepsis which is associated with decreased myocardial level of VEGF. Beta blocker plays crucial role in normalizing the sepsis-mediated decreased cardiac VEGF levels.
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| Free Research Field |
感染症
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