2015 Fiscal Year Final Research Report
Evaluation of brain metabolite for oxidative stress using microdialysis
| Project/Area Number |
25462821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKITA KENYA 香川大学, 医学部附属病院, 講師 (10505803)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳マイクロダイアリシス / 脳lactate/pyruvate / 脳ブドウ糖 / 心停止後症候群 |
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| Outline of Final Research Achievements |
Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue, and it has become the most accurate in vivo method to monitor brain metabolism. However, the association between CMD metabolites and blood lactate and glucose with respect to neurological outcomes in patients with non-traumatic OHCA remains unknown. The aim of this study was to examine the association between CMD metabolites and blood lactate and glucose in relation to neurological outcomes in these patients. In the preliminary microdialysis study, alterations of brain metabolites, such as lactate/pyruvate and glucose, during therapeutic hypothermia are associated with the neurological outcome in patients with out-of hospital cardiac arrest.
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| Free Research Field |
神経集中治療、重症脳障害
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