Manegement of lung epithelial cell response against invasive mechanical ventilation.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Hashimoto Soshi 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (60515279)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 人工呼吸関連肺障害

Outline of Final Research Achievements

Rats and mice were mechanically ventilated in lower tidal volume (6mL/Kg) or higher tidal volume (20mL/Kg and 40mL/Kg). Lung was removed and wet/dry ratio and albumin leakage was measured. We found increase in wet/dry ratio and albumin leakage in higher tidal volume group. Lung histology showed immune cell invasion after the mechanical ventilation with higher tidal volume.
Using this model, we investigated the expression of inflammatory cytokine and ERM proteins in the lung. We found that mechanical ventilation with higher tidal volume increased the amount of inflammatory cytokines and decreased the expression of ERM protein in the lung.
These result suggested that the relationship between the expression of ERM protein and the inflammatory reaction after the invasive mechanical ventilation.

Free Research Field

麻酔科学