2015 Fiscal Year Final Research Report
Development of pharmacotherapy which targets TGF beta /Smad signal for skin scarring.
| Project/Area Number |
25462829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MAKI KIDA 和歌山県立医科大学, 医学部, 講師 (00326381)
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| Co-Investigator(Kenkyū-buntansha) |
Ueda Kentaro 和歌山県立医科大学, 医学部, 講師 (20438279)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 瘢痕 / 創傷治癒 / TGFβ / オステオポンチン |
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| Outline of Final Research Achievements |
For development of scarring skin wound pharmacotherapy of which a target is TGF β / Smad signals, we studied skin wound healin osteopontin (OPN) knockout mice.
The wound healing of skin delayed, formation of granuration and TGFb signal were inhibited in OPN mice.OPN neutralizing antibody inhibited expressions of fibronectin,collagen Ia1,aSMA in wild type (WT) mice.OPN neutralizing antibody suppresed the formation of the granulation tissue and may inhibit scarring in skin wound.
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| Free Research Field |
集中治療
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