ATP/adenosine balance in SIRS

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Juntendo University
• Principal Investigator: SUMI YUKA 順天堂大学, 医学部, 准教授 (40403084)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Akihisa 日本医科大学, 医学部, 助手 (00366741) ; INOUE Yoshiaki 筑波大学, 医学部, 教授 (60379196) ; TANAKA Hiroshi 順天堂大学, 医学部, 教授 (90252676) ; SUEYOSHI Koichiro 順天堂大学, 医学部, 助手 (90648297)
• Research Collaborator: Junger Wolfgang Harvard Medical School, Department of Surgery, Beth lsrael Medical Deaconess Center, Professor
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ＳＩＲＳ / ＡＴＰ / ａｄｅｎｏｓｉｎｅ / Ｓｅｐｓｉｓ

Outline of Final Research Achievements

First, our data showed ATP/adenosine unbalance in various SIRS condition, such as sepsis, post-cardiac arrest syndrome, and Burn. ATP is pro-inflammatory factor and adenosine is anti-inflammatory factor, that the purinergic signaling may define the inflammatory response.
Second, we found that the ATP and ATP/adenosine before elective surgery may define the inflammatory response after surgery. This finding is intriguing that we can provide the custom made care for each patient depending on his ATP/adenosine profile before surgery.The mechanism of the difference in ATP/adenosine profile is unknown, and need to be clarified.

Free Research Field

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