Basic experiments for developing temporary packing material using a polymer gel to control solid organ hemorrhage

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Matsumoto Hisashi 日本医科大学, 医学部, 教授 (60242559)
• Co-Investigator(Kenkyū-buntansha): YAGI Takanori 日本医科大学, 医学部, 助教 (00445785) ; MASHIKO Kazuki 日本医科大学, 医学部, 助教 (40614805) ; YASUMATSU Hiroshi 日本医科大学, 医学部, 助教 (80614809)
• Co-Investigator(Renkei-kenkyūsha): HARADA Akira 大阪大学, 大学院理学研究科, 特任教授 (80127282) ; YAMAGUCHI Hiroyasu 大阪大学, 大学院理学研究科, 教授 (00314352) ; HASHITSUME Akihito 大阪大学, 大学院理学研究科, 准教授 (70294147) ; TAKASHIMA Yoshinori 大阪大学, 大学院理学研究科, 助教 (40379277)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 体幹部外傷 / ダメージコントロール / パッキング / 超分子ゲル / シクロデキストリン

Outline of Final Research Achievements

Removing of towel or gauze applied as a temporary hemostasis in damage control surgery causes for re-bleeding. This study aimed to develop a new material using a polymer gel that enables safe removal from the damaged organ after hemostatic packing.A polyacrylamide-based hydrogel containing β-cyclodextrin (CD) and adamantine (βCD-Ad gel) was applied to the crushed surface of the lacerated liver of a female pig to ascertain whether it could serve as packing material for hemorrhage control. The hardness, attachment and removability of the βCD-Ad gel were macroscopically evaluated. The hardness and fragmentation of the βCD-Ad gel is useful in packing to the injured organ surface. This experiment suggests that the polymer gel may be used as packing material instead of conventional gauze or towel and that it does not cause re-bleeding on removal. Trauma surgeons might be able to use a revolutionary hemostatic material for abdominal organ injury.

Free Research Field

外傷外科学