2015 Fiscal Year Final Research Report
Hydrogen Inhalation Protects Against Acute Lung Injury Induced by Hemorrhagic Shock and Resuscitation
| Project/Area Number |
25462840
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Michiko 神戸大学, 大学院保健学研究科, 保健学研究員 (40566121)
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| Co-Investigator(Renkei-kenkyūsha) |
KOTANI joji 兵庫医科大学, 医学部, 教授 (80360270)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 水素 / 出血性ショック / 肺障害 |
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| Outline of Final Research Achievements |
Hemorrhagic shock followed by fluid resuscitation (HS/R) leads acute lung injury (ALI). Hydrogen, atherapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects. Rats were subjected to hemorrhagic shock by withdrawing blood to lower blood pressure followed by resuscitation with shed blood and saline to restore blood pressure. After HS/R, the rats were maintained in a control gas of similar composition to room air or exposed to 1.3% hydrogen.
HS/R induced ALI, as demonstrated by significantly impaired gas exchange, congestion, edema, cellular infiltration, and hemorrhage in the lungs. Exposure to 1.3% hydrogen significantly attenuated the upregulation of neutrophil accumulation, alveolar cell wall thickness, oxidative stress, the mRNAs for several proinflammatory mediators induced by HS/R. Hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades.
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| Free Research Field |
救急・災害医学
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