2015 Fiscal Year Final Research Report
Pathology Elucidation and a Novel Therapeutic Strategy Against Sepsis-associated Encephalopathy
Project/Area Number |
25462842
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
|
Research Institution | Kurume University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
TAKASU Osamu 久留米大学, 医学部・救急医学講座, 教授 (90236216)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 敗血症 / 脳症 / エストロゲン / キヌレニン経路 / 盲腸結紮穿孔モデル |
Outline of Final Research Achievements |
In recent years, tens of millions of people worldwide develop severe sepsis every year, with comorbid encephalopathy increasing mortality in particular. We developed a mouse sepsis model in an attempt to elucidate the mechanisms of sepsis-associated encephalopathy. The model we used was the cecal ligation and puncture (CLP) model. After confirming improvements of survival rate via estrogen and L-kynurenine administrations, detection of mRNA expressions of a kynurenine receptor, the aryl carbohydrate receptor, and a tryptophanase, the tryptophan 2,3-dioxygenase, in peritoneal exudate cells were determined, indicating the involvement of the kynurenine pathway. In this process, we successfully generated a modified model in which intraperitoneal abscess formation, which is considered to be a defect of the original model, can be highly-controlled.
|
Free Research Field |
救急、集中治療
|