A novel therapeutic approach to severe burns by microskin grafts combined with ultra-thin nanosheets

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: National Defense Medical College
• Principal Investigator: SAITOH Diazoh 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 教授 (90531632)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 熱傷 / マイクロスキン / ナノシート / 感染制御

Outline of Final Research Achievements

Microskin grafting can be expanded more than 10-fold by mincing the skin grafts, and is an effective
method for the treatment of extensive burn injury. We recently fabricated biodegradable ultra-thin nanosheets, which have advantageous properties for their application as a wound dressing, such as transparency, tight adherence, and moisture permeability. This study aimed to investigate the efficacy of a microskin grafts (MSG) combined with nanosheets (NS) in the wound healing using burn wound models in mice. Treatment of the burn wounds with MSG/NS significantly accelerated the wound healing compared with non-treatment, characterized by an increased rate of re-epithelialization and remodeling. In addition, MSG/NS also enhanced platelet-derived growth factor expression and vascular networks of the wound bed in the early stages of repair. In conclusion, microskin grafting and nanosheets might be a possible new and effective procedure for repairing extensive burn wounds.

Free Research Field

救急医学