Oral carcinogenesis by disturbance of squamous differentiation regulated by Notch1

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462848
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Sakamoto Kei 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (00302886)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔癌 / Notch1

Outline of Final Research Achievements

We conducted chemical carcinogenesis experiments on mice by administering a carcinogenic agent by drinking water. Cancers and precancerous lesions like those of human developed in the oral cavity and esophagus. Ｗe created epithelial-specific conditional Notch1-knockout mice. These mice exhibited patchy hair loss with hyperplasia of hair follicles. Chemical carcinogenesis experiments revealed increased incidence of esophageal cancer in these mice compared with the wild type littermates. These results indicated that Notch1 plays an important role in development of oroesophageal cancer as a tumor-suppressor gene.

Free Research Field

口腔病理学