2016 Fiscal Year Final Research Report
Interactive effetcs of melatonin and mechanical stress on bone cells
Project/Area Number |
25462853
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphological basic dentistry
|
Research Institution | Okayama University |
Principal Investigator |
IKEGAME Mika 岡山大学, 医歯薬学総合研究科, 准教授 (70282986)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Toshio 岡山大学, 名誉教授 (30107776)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | メラトニン / 機械的刺激 / 骨組織 |
Outline of Final Research Achievements |
To develop a new method for treatment of bone disease, we examined effects of melatonin on bone tissue. MT2, one of the isoforms of melatonin receptor, was the major type expressed in mouse bone tissue. It was expressed not only in osteoblasts, as has been reported previously, but also in some osteocytes and osteoclasts. The expression level of MT2 in osteocytes which located close to the endosteum tended to be higher at night compared to that at day time. It was also suggested that melatonin suppressed the up-regulated activity of osteoclasts cultured under modeled microgravity.
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Free Research Field |
骨組織細胞形態学
|