Effect of F-spondin on the inhibition of alveolar bone resorption

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462854
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Kitagawa Masae 広島大学, 大学病院, 助教 (10403627)
• Co-Investigator(Kenkyū-buntansha): TAKATA TAKASHI 広島大学, 医歯薬保健学研究院(歯), 教授 (10154783) ; MIYAUCHI MUTSUMI 広島大学, 医歯薬保健学研究院(歯), 准教授 (50169265)
• Co-Investigator(Renkei-kenkyūsha): OKA HIROKO 広島大学, 医歯薬保健学研究院(歯), 特任講師 (60452588)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: F-spondin / 骨芽細胞 / IL-6 / 抗炎症作用

Outline of Final Research Achievements

In cementblast forming hard tissue as osteoblast, F-spondin not only promotes calcification but also inhibits IL-6 expression and PGE2 production stimulated by LPS, and it suppresses osteoclast differentiation. In this study, we examined effects of F-spondin on the anti-inflammatory reaction to osteoblast and the inhibition of alveolar bone resorption. In osteoblasts, F-spondin suppressed IL-6 expression in vitro study. In vivo study, the alveoral bone resorption caused by Inflammation was suppressed in the F-spondin overexpressing transgenic mice, but it was difficult to control the periodontitis by use of F-spondin peptide in vivo study.

Free Research Field

口腔病理学