2015 Fiscal Year Final Research Report
Elucidation of the pathogenesis pain mechanism in the trigeminal nerve area with a focus on Toll-like receptor
Project/Area Number |
25462856
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphological basic dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
Watanabe Mineo 広島大学, 医歯薬保健学研究院, 助教 (80325183)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 口腔解剖学 / 病態痛 |
Outline of Final Research Achievements |
Pathogenic mechanism of extra-territorial facial pain induced by the mental nerve transection were clarified by focusing on Toll-like receptor 4 (TLR4), inflammatory cytokines and intracellular signaling system. In addition, it was also studied bovine lactoferrin application to the extra-territorial facial pain. IL-18 induction via TLR4-derived p38 MAPK signaling pathways in microglia might play an important role in mental nerve transection-induced extra-territorial pain. Further, bovine lactoferrin suppresses the production of the phosphorylation of p38 MAPK and IL-18, and may exert an analgesic effect.
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Free Research Field |
口腔解剖学
|