Elucidation of the pathogenesis pain mechanism in the trigeminal nerve area with a focus on Toll-like receptor

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462856
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Watanabe Mineo 広島大学, 医歯薬保健学研究院, 助教 (80325183)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔解剖学 / 病態痛

Outline of Final Research Achievements

Pathogenic mechanism of extra-territorial facial pain induced by the mental nerve transection were clarified by focusing on Toll-like receptor 4 (TLR4), inflammatory cytokines and intracellular signaling system. In addition, it was also studied bovine lactoferrin application to the extra-territorial facial pain. IL-18 induction via TLR4-derived p38 MAPK signaling pathways in microglia might play an important role in mental nerve transection-induced extra-territorial pain. Further, bovine lactoferrin suppresses the production of the phosphorylation of p38 MAPK and IL-18, and may exert an analgesic effect.

Free Research Field

口腔解剖学