A study of cellular signaling of PP2A inhibitor during the tooth development

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462862
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: Nagata Kengo 九州大学, 歯学研究科(研究院), 助教 (90189134)
• Co-Investigator(Kenkyū-buntansha): KIYOSHIMA Tamotsu 九州大学, 大学院歯学研究院, 教授 (20264054) ; WADA Hiroko 九州大学, 大学院歯学研究院, 助教 (70380706) ; FUJIWARA Hiroaki 九州大学, 大学院歯学研究院, 助教 (50634200) ; SAKAI Hidetaka 九州大学, 大学院歯学研究院, 教授 (80136499)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 歯の発生 / エナメル質形成 / 象牙質形成 / I2PP2A / FRG1

Outline of Final Research Achievements

Odontogenesis is regulated by the sequential and reciprocal epithelial-mesenchymal interactions through the various growth factors and cytokines. We previously performed cDNA subtraction between mouse mandibles collected on embryonic days 10.5 and 12.0 to identify the genes, including protein phosphatase 2A inhibitor 2 (I2PP2A) and facioscapulohumeral muscular dystrophy region gene 1 (FRG1). In this study, we show the specific expression of I2PP2A and FRG1 during the mouse tooth morphogenesis. The expression and localization of FRG1 were also shown using the mouse odontogenic epithelial cell line. Our present findings indicate that I2PP2A and FRG1 may play important roles in mouse tooth morphogenesis.

Free Research Field

口腔病理学