2015 Fiscal Year Final Research Report
Study of localization mechanism of cell surface proteins in Porphyromonas gingivalis
| Project/Area Number |
25462863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHOJI Mikio 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10336175)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 歯周病細菌 / リポ多糖 |
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| Outline of Final Research Achievements |
The periodontal pathogen Porphyromonas gingivalis has approximately 30 proteins (called CTD proteins) that contain a conserved C-terminal domain. We have reported that CTD proteins are secreted onto the cell surface via the Type IX secretion system, and some of CTD proteins are anchored on the cell surface by binding to A-LPS. However, the mechanism of A-LPS biosynthesis remains to be determined.
In this study, we found that WzzP, Wzx, WbaP, PGN_0002 are involved in the A-LPS biosynthesis.
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| Free Research Field |
口腔病原微生物学
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