Investigation of DNA methylation in the multiple oral squamous cell carcinomas

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Kagoshima University
• Principal Investigator: Shima Kaori 鹿児島大学, 医歯学域歯学系, 助教 (10343526)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔扁平上皮癌 / 多発癌 / メチル化 / エピジェネティクス / 前癌病変 / 領域発がん

Outline of Final Research Achievements

We have been investing DNA methylation of the promoter region of tumor suppressor genes in the multiple oral squamous cell carcinomas with the concept of field cancerization. The twenty-seven multiple oral squamous cell carcinomas were picked up from o among the 438 primary oral squamous cell carcinomas from our institutional pathology records. The three cases were suspected radiation for the primary lesion induced second carcinoma at other site.

Free Research Field

口腔病理学