The basic study on the molecular mechanism and development of therapeutic agent for type II diabetic periodontitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Zhang Min 九州歯科大学, 歯学部, 助教 (00326472)
• Co-Investigator(Kenkyū-buntansha): Jimi Eijiro 九州歯科大学, 歯学部, 教授 (40276598) ; Matsuo Kou 九州歯科大学, 歯学部, 教授 (70238971) ; Fukushima Hidefumi 東北大学, 歯学研究科, 准教授 (70412624)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖尿病性歯周炎 / レプチン / 破骨細胞

Outline of Final Research Achievements

Non-insulin-dependent type II diabetes mellitus causes serious complications, such as hypertension and arteriosclerosis, as well as diabetic periodontitis. In the present study, a model of type II diabetes periodontitis was developed using leptin receptor-deficient mice (db/db mice), and the mechanism of diabetic periodontitis in the model was clarified. As a model of experimental periodontitis, LPS was injected into the first right mandibular molar and mesial buccal gingiva of both db/db mice and wild type mice three times per week, for four weeks. We found that the alveolar bone resorption due to the large number of osteoclasts was significantly higher in the db/db group than in the WT group. We also clarified that leptin inhibited osteoclast formation by inhibiting the expression of RANK of the osteoclast outrider cell and c-fms, as well as by inhibiting the rise in the expression of RANKL of osteoblasts .

Free Research Field

口腔病態病理学分野