2015 Fiscal Year Final Research Report
Structural and functional studies of dipeptidyl aminopeptidases from periodontal pathogen.
| Project/Area Number |
25462872
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Nobutada 昭和大学, 薬学部, 准教授 (00286866)
OGASAWARA Wataru 長岡技術科学大学, 工学部, 教授 (40292172)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | DPP11 / S46 / ペプチダーゼ / 抗菌薬 / 結晶構造解析 / 歯周病 |
|---|
| Outline of Final Research Achievements |
The morbidity of periodontal disease is reported to be 50% above in population worldwide. Some Non-Fermenting Gram-Negative Rods (NFGNR) may cause periodontal disease, such as Porphyromonas gingivalis.
NFGNR is well known as that utilize peptides as energy and carbon sources instead of carbohydrates. DPPs (Dipeptidyl aminopeptidase) are peptide degradation enzymes that play a key part in intake of peptides.
Bacterial DPPs are divided into two categories (Clan SC S9, Clan PA S46). Interestingly, DPPs of Clan PA S46 are only found in bacteria. Our X-ray crystallographic studies of Pseudomonas mexicana WO24 DAP BII and Porphyromonas gingivalis DPP11 revealed that catalytic mechanism and substrate recognition mechanism. These findings are useful in the development of specific inhibitors for S46 peptidases.
|
| Free Research Field |
構造生物薬学
|
