The study on the mechanism of nerve paralysis and its application for the therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Osaka University
• Principal Investigator: Toyoda Hiroki 大阪大学, 歯学研究科, 准教授 (00432451)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 漏洩カリウムチャネル / 運動ニューロン / 一酸化窒素 / cGMP / 三叉神経 / 顔面神経 / 入力抵抗 / スパイク

Outline of Final Research Achievements

In the present study, we studied the mechanism of nerve paralysis by focusing on the role of leak K+ channels expressed in motoneurons. Following application of 8-Br-cGMP, input resistances were decreased and spike onsets were delayed in small-sized motoneurons (< 20 μm), while input resistances and spike onsets remained almost unchanged in large-sized motoneurons (> 35 μm). These results suggest that activation of NO-cGMP-PKG pathway alters membrane excitability of motoneurons through the modulation of activities of leak K+ currents. Such neural mechanisms are likely to be involved in the generation of neural paralysis.

Free Research Field

神経科学