2016 Fiscal Year Final Research Report
The study on the mechanism of nerve paralysis and its application for the therapy
Project/Area Number |
25462885
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Osaka University |
Principal Investigator |
Toyoda Hiroki 大阪大学, 歯学研究科, 准教授 (00432451)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 漏洩カリウムチャネル / 運動ニューロン / 一酸化窒素 / cGMP / 三叉神経 / 顔面神経 / 入力抵抗 / スパイク |
Outline of Final Research Achievements |
In the present study, we studied the mechanism of nerve paralysis by focusing on the role of leak K+ channels expressed in motoneurons. Following application of 8-Br-cGMP, input resistances were decreased and spike onsets were delayed in small-sized motoneurons (< 20 μm), while input resistances and spike onsets remained almost unchanged in large-sized motoneurons (> 35 μm). These results suggest that activation of NO-cGMP-PKG pathway alters membrane excitability of motoneurons through the modulation of activities of leak K+ currents. Such neural mechanisms are likely to be involved in the generation of neural paralysis.
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Free Research Field |
神経科学
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