2015 Fiscal Year Final Research Report
Inhibitory mechanism of rhinacanthin C on osteoclast formation
| Project/Area Number |
25462898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Shirataki Yoshiaki 城西大学, 薬学部, 教授 (60077980)
Suzuki Ryuichiro 城西大学, 薬学部, 助教 (20415201)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 破骨細胞 / 骨吸収 / 骨粗鬆症 / 生薬 |
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| Outline of Final Research Achievements |
Bone formation by osteoblasts and bone resorption by osteoclasts are balanced to maintain bone homeostasis. Enhanced bone resorption can lead to bone fracture seen in osteoporosis. We found that rhinacanthin C isolated from R.nasutus has a strong anti-osteoclast formation effect. Rhinacanthin C dose-dependently and reversibly suppressed RANKL-induced osteoclast differentiation and expression of NFATc1, which is an essential transcription factor for osteoclast differentiation. Rhinacanthin C also suppressed endotoxin LPS-stimulated osteoclastogenesis from cultured bone marrow cells. Furthermore, rhinacanthin C protected RANKL or LPS induced mouse calvarial osteolysis in vivo.
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| Free Research Field |
生化学
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