2015 Fiscal Year Final Research Report
Elucidation of molecular mechanisms for osteoclast polarization through Wnt5a-Ror2 signaling
Project/Area Number |
25462904
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Yasuhiro 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 破骨細胞 / Wnt / 非古典経路 / 骨吸収 / Rho |
Outline of Final Research Achievements |
Polarization of osteoclasts (formation of actin rings and ruffled borders) is necessary to resorb bone. We examined the molecular mechanisms regulating osteoclast polarization through the cytokine Wnt5a and co-receptor Ror2 in osteoclasts. We revealed that Wnt5a-Ror2 signaling regulates the bone-resorbing activity of osteoclasts through the activation of Rho-Pkn3 pathways, and that Daam2, an adaptor molecule, is involved in activation of Rho under the Ror2 signaling.
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Free Research Field |
生化学
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