2015 Fiscal Year Final Research Report
Roles of an atypical Wnt receptor, Ryk, for bone remodeling
| Project/Area Number |
25462905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
Nakamichi Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
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| Co-Investigator(Kenkyū-buntansha) |
Udagawa Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Ryk / Wnt / 破骨細胞 / 骨芽細胞 |
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| Outline of Final Research Achievements |
Wnt signaling is involved in virtually every aspect of embryonic development, and also homeostatic self-renewal and aging in a variety of adult tissues. Ryk is the latest member of the Wnt receptors. Ryk does not belong to the conventional classification of the Wnt-promoted signal transduction. Therefore, little is known about its mechanism of action. Ryk may be involved in Wnt-regulated processes in bone remodeling. In this study, we elucidated roles of Ryk for bone and mineral metabolism by using Ryk conditional KO mice lines that are established in our laboratory.
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| Free Research Field |
分子生物学
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