Application of biglyan as tumor biomarker of oral cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Hokkaido University
• Principal Investigator: Ono Mitsunobu 北海道大学, 大学病院, 講師 (50281829)
• Co-Investigator(Kenkyū-buntansha): OHGA Noritaka 北海道大学, 大学院歯学研究科, 助教 (40548202) ; KITAMURA Tetsuya 北海道大学, 大学院歯学研究科, 助教 (00451451) ; SHINDOH Masanobu 北海道大学, 大学院歯学研究科, 教授 (20162802)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腫瘍血管内皮細胞 / Biglycan / プロテオグリカン / 腫瘍マーカー

Outline of Final Research Achievements

We focused on biglycan which is proteoglycan and a published-tumor endothelial markers. Since the function of biglycan has not been fully evaluated, we addressed the role of biclycan in tumor vasculature in oral cancer in this study. We showed that biglycan is involved in tumor endothelial cell migration. The biglycan plasma level was elevated in cancer patients compared to that in normal volunteer. Finally, we tried to establish the system for targeting biglycan in tumor endothelial cells using drug delivery system which contains biglycan siRNA.

Free Research Field

口腔がん