Analysis of the metastatic activity of headn and neck cancer from the asepect of lymphangiogenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohto College of Health Sciences
• Principal Investigator: Katsube Ken-ichi 東都医療大学, ヒューマンケア学部, 教授 (20233760)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: Notch / 脈管新生 / 癌転移

Outline of Final Research Achievements

Coculture of the oral Squamous cell carcinoma (SCC) and fibroblasts showed the significant upregulation of Notch3 among Notch receptor family. Separation analysis revealed that the fibroblasts are responsible for Notch3 upregulation and carcinoma cells express JAG1. Triple coculture of oral SCC, fibroblasts and HUVEC showed an accelerated vasculogenesis. Oral SCC cell lines are classified into Notch3-inducing type and Notch3-non-inducing type, in which the Notch3-inducing cell lines have highly active growth in vivo. Analysis of the clinical cases of oral SCC revealed that Notch3-inducing type has higher malignant activity. Oral SCC may induce not only CAF to produce an favorable environment, but also vasculogenesis to promote metastasis.

Free Research Field

病理学