The fate of cells dependent on p53 and FEN1

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462922
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nagasaki University
• Principal Investigator: KATAYAMA Ikuo 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (80295089)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Takashi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30172406) ; HOTOKEZAKA Yuka 長崎大学, 病院(歯学系), 講師 (10244089) ; TASHIRO Shigeki 長崎大学, 病院(医学系), 助教 (20300882) ; SASAKI Miho 長崎大学, 病院(歯学系), 助教 (10437874)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: p53 / FEN1 / 細胞老化 / 細胞死

Outline of Final Research Achievements

We investigated whether the balance between p53 and FEN1 decide the fate of cells. Inhibition of FEN1 induced celler senescence in p53 mutant T24 cells, but induced cell death in p53 wild type T24 cells. On the other hand, inhibition of FEN1 induced cell death in p53 wild type HCT116 cells, but did not induce celler senescence and cell death in p53 deficient HCT116 cells. These results suggest that relationship between p53 and FEN1 may decide the fate of cells.

Free Research Field

歯科放射線学