2015 Fiscal Year Final Research Report
Role of MUC1 regulated by stress-responsed micro RNA
| Project/Area Number |
25462923
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOTOKEZAKA Yuka 長崎大学, 病院(歯学系), 講師 (10244089)
KATAYAMA Ikuo 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (80295089)
ICHIKAWA Yoko 長崎大学, 病院(歯学系), 助教 (90380857)
NAKAMURA Takashi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30172406)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | MUC1 / マイクロRNA / ストレス応答 / cPLA2 / GAP結合 |
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| Outline of Final Research Achievements |
MUC1 is a transmembrane glycoprotein that modulates transcription via its cytoplasmic domain. We originally paid attention to the MUC1 function under the environmental stresses such as ionizing radiation, UV, heat-shock, Hypoxia. Particularly we think that MUC1 expression control through the micro RNA may take the role that is important to stress correspondence.
As a result of having inspected it about a reply to hypoxia about the MUC1 protein, in HeLa S3 cell cultured under a hypoxia, an expression of MUC1 level decreased within 2 hours after a culture start and decreased in the level that expression of MUC1 could not detect in 6 hours later. After transfecting siRNA of the cause protein candidate -alpha NAC and gamma taxilin, MUC1 expression level decreased, the data which suggested positively were provided.
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| Free Research Field |
分子生物学
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