White spot lesions remineralization by chewing sugar-free gum containing bio-available calcium and fluoride: A double-blind randomized controlled trial

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462946
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Kitasako Yuichi 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (30361702)
• Co-Investigator(Kenkyū-buntansha): SADR Alireza 東京医科歯科大学, 医歯学総合研究科, GCOE 特任講師 (20567755) ; SHIMADA Yasushi 東京医科歯科大学, 医歯学総合研究科, 助教 (60282761) ; TAGAMI Junji 東京医科歯科大学, 医歯学総合研究科, 教授 (50171567)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 初期エナメル質う蝕 / シュガーレスガム / 再石灰化 / カルシウム / フッ化物 / ICDAS / OCT

Outline of Final Research Achievements

The aim of this study was to assess the effect of chewing gums containing POs-Ca and fluoride on natural WSL remineralization in comparison with POs-Ca or placebo (control) chewing gums, in double- blind, randomized, controlled trial. The subjects were randomly divided into three groups and chewed two slabs of each gum three times every day. Each subject followed this regimen for 3 months and attended a monthly review appointment. WSL was assessed using ICDAS criteria and optical boundary depth (BD) recovery rate as a measure of lesion depth by OCT system at a monthly review. This double-blind, randomized, controlled trial study highlights the importance of calcium and fluoride ion bioavailability in the reinforcement of demineralized enamel while the recovery potential of natural WSL was variable among the cases studied in the course of consuming the POs-Ca F chewing gum.

Free Research Field

歯学