2015 Fiscal Year Final Research Report
Identification and application of degraded dentin matrix components as a pulp capping agent
| Project/Area Number |
25462958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSAWA SATORU 大阪大学, 歯学研究科, 教授 (30243249)
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| Research Collaborator |
OKAMOTO MOTOKI
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 歯学 / 覆髄 / 象牙質 / 歯髄 / 再生 |
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| Outline of Final Research Achievements |
Dentin matrix components (DMCs) can be degraded by proteinase like MMP molecules. Degraded DMCs by MMPs were found to promote the various functions of pulpal cells in vitro and also promote the wound healing process of dentin-pulp complex in vivo from the results of this study. Especially, degraded DMCs induced by MMP20 showed higher healing ability compared to other MMP molecules. To identify the components of the degraded DMCs by MMP20, proteome analysis was performed and eight candidate proteins were acquired from the analysis. From these results, the candidate molecules had possibilities to promote pulpal repair process and development of true biological pulp capping agent might be possible in the near future.
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| Free Research Field |
保存治療系歯学
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