2015 Fiscal Year Final Research Report
Establishment of biological direct pulp capping method with the agent inducing HSPs
Project/Area Number |
25462979
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Conservative dentistry
|
Research Institution | Kyushu Dental College |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 直接覆髄 / heat shock protein / 歯髄 / 炎症 / 象牙質形成 |
Outline of Final Research Achievements |
The aim of this study is establishment of the therapy that makes a biological direct pulp capping. At first, we identified the crucial role of the heat shock protein (HSP) 70 to protect against various stimulus in cells derived from pulp and this results suggests the possibility of HSP70 inducer for direct pulp capping. Next, we investigated inflammatory response mechanism of pulp cells and potential of novel anti-inflammatory agent for pulp cells. Furthermore, we evaluated several methods to induce regenerated dentin formation with proper quality and quantity. We found that platelet-rich plasma and bioactive glass enhance hard tissue formation as well as differentiation of odontoblastic cells. As mentioned above, we obtained evidence about the capability of the biological pulp capping method in a series of the studies.
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Free Research Field |
歯科保存学
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