2015 Fiscal Year Final Research Report
Preparation of osteo-conductive device using nano-size apatite particles
| Project/Area Number |
25463013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 生体材料 / ナノアパタイト / コラーゲン / 複合体 / 硬組織再生 / 医療デバイス / 架橋型ヒアルロン酸 / BMP |
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| Outline of Final Research Achievements |
We prepared collagen/nano-apatite composites by blending, and implanted them in rat cranial defects. It became evident that sponge composites were absorbed, but pressed composites had good osteo-conductive properties, leading to much new bone formation. It was suggested that pressed collagen/nano-apatite composites are new bone substitute materials.
We also prepared crosslink-type hyaluronic acid/nano-apatite/BMP sols, and implanted them in mouse head, back and muscle. The materials (gel) induced bone formation at high rates. It was speculated that crosslink-type hyaluronic acid/nano-apatite/BMP composite might be used as safe injectable (sol-gel reaction type) osteo-cunductive medical device.
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| Free Research Field |
歯科理工学
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