2015 Fiscal Year Final Research Report
Bone regeneration by hypertrophic cartilage cells using iPS cells as cell source
| Project/Area Number |
25463041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Yoshitomo 大阪歯科大学, 歯学部, 講師 (90547259)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | iPS細胞 / 骨再生 |
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| Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) are considered a potential autologous therapy for tissue engineering. The available procedures for MSC retrieval from patients are invasive, and their limited in vitro proliferation restricts their use in the treatment of damaged tissues. Therefore, it is important to establish an alternative and safe source of MSCs.
The objective of this study was to demonstrate induced pluripotent stem cell (iPSC) generation from a combination of an accessible source tissue and an integration-free method; we also attempted the differentiation of iPSCs into MSC-like cells (MSLCs) for future autologous tissue engineering.
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| Free Research Field |
歯科理工学
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