The mechanism identification of environmental selective bone induction/suppression of BMP-2

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463050
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Okayama University
• Principal Investigator: Nawachi Kumiko 岡山大学, 大学病院, 助教 (10379787)
• Co-Investigator(Kenkyū-buntansha): KUBOKI TAKUO 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195) ; SONOYAMA WATARU 岡山大学, 岡山大学病院, 講師 (40325121) ; ONO MITSUAKI 岡山大学, 大学院医歯薬学総合研究科, 助教 (60613156) ; AKIYAMA KENTARO 岡山大学, 岡山大学病院, 講師 (70423291) ; SHINKAWA SHIGEHIKO 岡山大学, 岡山大学病院, 医員 (10727465)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨形成 / BMP-2 / 骨髄 / 口腔インプラント / オッセオインテグレーション

Outline of Final Research Achievements

Recombinant human BMP-2 (rhBMP-2) has been widely used to treat bone defects or bone-associated diseases in human. However, recently our research group found that rhBMP-2 inhibited bone formation in in the bone marrow space. The purpose of this research was to elucidate the mechanism of environmental selective bone induction/suppression of BMP-2. In the mice model, BMP-2 could not induce the bone formation in the bone marrow rich environment. Moreover, large animal model experiments revealed that rhBMP-2 were suitable for operative procedure in the bone marrow poor environment, such as socket lift and socket preservation.

Free Research Field

歯科補綴学