New development of periodontal regenerative therapy using growth factors and orthodontic mechanical stress

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kagoshima University
• Principal Investigator: SHIRAKATA YOSHINORI 鹿児島大学, 医歯学域歯学系, 准教授 (60359982)
• Co-Investigator(Kenkyū-buntansha): BANDOU Kenjiro 明海大学, 歯学部, 講師 (50347093) ; YAMAMOTO Yoshitake 鹿児島大学, 医歯学域歯学系, 助教 (50380465)
• Research Collaborator: Miron Richard J. ; Bosshardt Dieter ; Sculean Anton
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 歯周組織再生療法 / 成長因子 / エナメルマトリックスプロテイン / テイッシュエンジニアリング / 矯正治療 / メカニカルストレス

Outline of Final Research Achievements

It is reported that enamel matrix protein derivative (EMD) enhances periodontal regeneration and an optimal mechanical stress (MS) has a positive effect on bone healing. One-wall intrabony defects were fabricated in bilateral mandibular premolars in beagle dogs, and the premolars were moved into the defects using orthodontic devices. The present study evaluated the effects of MS, autogenous bone grafting (AG) and EMD on periodontal regeneration in the experimental model. Consequently, tooth movement occurred without any complications and the AG and EMD treatment provided more favorable periodontal regeneration characterized by new attachment in the defects when compared to AG alone. These findings indicate that the MS, AG and EMD treatment may be a new approach in periodontal regenerative therapy.

Free Research Field

歯周病学